(Montelukast Sodium). Tablets, Chewable Tablets, and Oral Granules demonstrated that montelukast does not inhibit CYP2C8 in vivo, and therefore is not anticipated to alter the metabolism of drugs metabolized by this enzyme (see Drug Interactions). Elimination. The plasma clearance of montelukast averages 45 mL/min. Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually Evgeny Shapiro, Ronit Yahalomi, Valerie Niddam-Hildesheim, Greta Sterimbaum, Kobi Chen, "Processes for preparing montelukast sodium." U.S. Patent Identification · Pharmacology · Interactions · References.
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It is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids, if they alone do not bring the desired effect. It is also used to prevent allergic reactions and asthma flare-ups during the administration of intravenous immunoglobulin. Montelukast is administered as montelukast sodium, with mg Medical uses · Adverse effects · Drug interactions · Uses under study. In vitro studies using human liver microsomes indicate that cytochromes P 3A4 and 2C9 are involved in the metabolism of Montelukast sodium. Clinical studies investigating the effect of known inhibitors of cytochromes P 3A4 (e.g. ketoconazole, erythromycin) or 2C9 (e.g. fluconazole) on montelukast.
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