Portier and Richet first coined the term anaphylaxis in when a second vaccinating dose of sea anemone toxin caused a dog's death. The term is derived from the Greek words ana - (“up, back, again”) and phylaxis (“guarding, protection, immunity”). INTRODUCTION — Anaphylaxis is a potentially fatal disorder that is under-recognized and undertreated. This may partly be due to failure to appreciate that anaphylaxis is a much broader syndrome than "anaphylactic shock," and the goal of therapy should be early recognition and treatment with.
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Peds: mg/kg (max mg/ dose) to thigh every 5 min up to 3 doses. Epinephrine IV infusion: ( mg/mL) mcg/kg/min if patient is refractory to multiple IM epinephrine doses. Antihistamines. H1 Blocker: Diphenhydramine. Adult: 50 mg IV or Oral. Peds: 1 mg/kg (max 50mg) IV or Oral. H2 Blocker: Famotidine. severe anaphylaxis. The mainstays of treatment of urticaria are the H1 and H2 receptor anatagonists, most effective when given in combination intravenously. angioedema or severe anaphylaxis should be given epinephrine auto-injectors prior to . or famotidine [Pepcid] 20mg) has been demonstrated to be more.
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