Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia. Leonard CE(1), Bilker WB For antidepressants having nonnull risks (bupropion and mirtazapine), we observed no relationship with antidepressant dose and some relationships with concomitant cytochrome P inhibition. In overdose ranges, this delayed conduction may even cause complete heart block or ventricular reentry arrhythmia, which can ultimately lead to death. . Similarly, TCAs, Citalopram, Fluoxetine, Paroxetine, and Mirtazapine have been reported to cause TdP most often in patients with other risk factors, at toxic levels, or in.
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breast engorgement, breast enlargement, urinary urgency. Other Adverse Events Observed During Postmarketing Evaluation of REMERON. Adverse events reported since market introduction, which were temporally (but not necessarily causally) related to mirtazapine therapy, include 4 cases of the ventricular arrhythmia. degree of QT prolongation observed with both 45 mg (therapeutic) and 75 mg. (supratherapeutic) doses of mirtazapine was not at a level generally considered to be clinically meaningful. During the postmarketing use of mirtazapine, cases of QT prolongation, Torsades de Pointes, ventricular tachycardia, and sudden death.
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