More importantly, the use of single doses of two drugs administered together (optimally albendazole with DEC or ivermectin) is 99% effective in removing microfilariae from the blood for a full year after treatment. This level of treatment effectiveness has made feasible new efforts to eliminate lymphatic filariasis. Treating. Diethylcarbamazine (DEC) is the drug of choice in the United States. The drug kills the microfilaria and some of the adult worms. DEC has been used world-wide for more than 50 years. Because this infection is rare in the U.S., the drug is no longer approved by the Food and Drug Administration (FDA) and.
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The two alternative regimens are: single doses of albendazole (mg) plus Mectizan® ( mg/kg/body wt) or single doses of albendazole (mg) plus DEC (6mg/kg/body wt). DEC, developed over 50 years ago, is an inexpensive and effective anti-filarial drug which is used to treat LF in many countries. DEC is. It found that it resulted in complete microfilarial clearance, as well as a more sustained clearance than that resulting from standard-dose albendazole-ivermectin treatment. Another study demonstrated that a 3-drug regimen (DEC, albendazole, ivermectin) resulted in better outcomes and fewer adverse.
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